Linker For Activation Of T-Cells Family, Member 2 (LAT2) Antibody
260€ (50 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Linker For Activation Of T-Cells Family, Member 2 (LAT2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx339719
tested applications
ELISA, IHC
Description
LAT2 Antibody is a Rabbit Polyclonal against LAT2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Linker For Activation Of T-Cells Family, Member 2 (LAT2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/5000, IHC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9GZY6 |
| Gene ID | 7462 |
| Alias | LAT2,LAB, NTAL, WBSCR15, WBSCR5, WSCR5, HSPC046 |
| Background | Antibody anti-LAT2 |
| Status | RUO |
Descripción
Linker for activation of T-cells family member 2 (LAT2), also known as NTAL (Non-T cell Activation Linker), is an adaptor protein expressed in various immune cells, including B cells, mast cells, and NK cells. LAT2 functions analogously to LAT by facilitating signal transduction from immunoreceptors, such as the B-cell receptor (BCR) and Fc receptors, to downstream signaling cascades. Upon receptor engagement, LAT2 undergoes tyrosine phosphorylation, enabling it to recruit signaling molecules, such as Grb2 and PLCγ, which are essential for calcium mobilization and activation of the MAPK pathway. LAT2 plays a crucial role in immune responses, particularly in B-cell activation, mast cell degranulation, and cytokine production. Unlike LAT, LAT2 exhibits a broader expression pattern and participates in both adaptive and innate immunity. Its dysregulation has been implicated in allergic reactions and immune cell hyperactivity, making it a potential therapeutic target in allergic and inflammatory diseases.
Related Products
Recombinant Human LAT2
Ver Producto
Linker For Activation of T-Cells Family, Member 2 (LAT2) Antibody
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein.
Ver Producto
Human Linker For Activation Of T-Cells Family, Member 2 (LAT2) Protein
Recombinant Linker For Activation Of T-Cells Family, Member 2 (LAT2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Ver Producto