Linker For Activation Of T-Cell Phospho-Tyr191 (LAT pY191) Antibody

Documentos del producto

Especificaciones del producto

Primary Antibodies

Target: Linker For Activation Of T-Cell Phospho-Tyr191 (LAT pY191)
Immunogen: Synthesized peptide derived from human LAT around the phosphorylation site of Y191.

Rabbit

Human, Mouse, Rat

ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by affinity chromatography.

50 µg

100 µg

Liquid

ELISA, WB, IHC

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

O43561

27040

LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36

Antibody anti-LAT

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.