Linker For Activation Of T-Cell (LAT) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Linker For Activation Of T-Cell (LAT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004320
tested applications
WB
Description
LAT Antibody is a Rabbit Polyclonal antibody against LAT. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Linker For Activation Of T-Cell (LAT) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43561 |
| Gene ID | 27040 |
| NCBI Accession | NP_055202.1 |
| Alias | LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36 |
| Background | Antibody anti-LAT |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.
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