Linker For Activation Of T-Cell Phospho-Tyr191 (LAT pY191) Antibody
Pida mas información
935106861
info@markelab.com
Precio
52€ (10 µg)
Antibody anti-LAT
proveedor
Abbexareference
abx249420Tested Applications
ELISA, WB, IHCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
LAT pY191 Antibody is a Rabbit Polyclonal for the detection of LAT phosphorylated at: Human: Tyr191; Mouse: Tyr195; Rat: Tyr195.
Background
The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Linker For Activation Of T-Cell Phospho-Tyr191 (LAT pY191)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
recommended dilution
ELISA: 1/1000, WB: 1/500 - 1/3000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
size 1
10 µg
size 2
100 µg
size 3
200 µg
size 4
300 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
LAT
dry ice
No
availability
Shipped within 5-10 working days.
alias
LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36
uniprot id
note
Concentration: 1 mg/ml -
Quizá le pueda interesar
Human LAT(Linker For Activation of T-cell) ELISA Kit
proveedor
FineTestreference
EH3288reactivity
humanstatus
RUOPrecio a consultar
Ver másMouse LAT(Linker for activation of T cell) ELISA Kit
proveedor
FineTestreference
EM1183reactivity
mousestatus
RUOPrecio a consultar
Ver másanti- LAT antibody
proveedor
FineTestreference
FNab04706Tested Applications
ELISA, WB, IHCreactivity
human,mousestatus
RUOclonality
polyclonalRequired for TCR(T-cell antigen receptor)-and pre-TCR-mediated signaling, both in mature T-cells and during their develo...
Precio a consultar
Ver más