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Linker For Activation Of T-Cell (LAT) Cell ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
493.75€ (96 tests)
Elisa Kits LAT
proveedor
Abbexareference
abx595353Tested Applications
ELISAreactivity
Human, Mouse, Ratstatus
RUOclonality
Descripción
LAT Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Background
The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.
Características del producto
category
ELISA Kits
immunogen target
Linker For Activation Of T-Cell (LAT)
reactivity
Human, Mouse, Rat
detection method
Colorimetric
sample type
Cell ELISA
size 1
96 tests
alias
LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
LAT
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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