Linker For Activation Of T-Cell (LAT) Cell ELISA Kit
513.5€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Linker For Activation Of T-Cell (LAT) Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595353
Tested Applications
ELISA
Description
LAT Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Linker For Activation Of T-Cell (LAT) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O43561 |
| Gene ID | 27040 |
| OMIM | 602354 |
| Alias | LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36 |
| Background | Elisa Kits for: LAT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.
Productos relacionados
Linker For Activation Of T-Cell (LAT) Antibody
LAT Antibody is a Rabbit Polyclonal antibody against LAT. The protein encoded by this gene is phosphorylated by ZAP-70/S…
Ver producto
Linker For Activation Of T-Cell (LAT) Antibody
Rabbit polyclonal antibody against LAT protein. Immunogen region is C-terminal.…
Ver producto
Human Linker for activation of T-cells family member 1 (LAT) ELISA Kit
Human Linker for activation of T-cells family member 1 (LAT) ELISA Kit is an ELISA Kit for the in vitro quantitative mea…
Ver producto