Linker For Activation of T-Cell (LAT) Antibody

Product specifications

Primary Antibodies

Linker For Activation of T-Cell (LAT)

Mouse

Human

WB: 1-2 μg/ml, FCM: 1-4 μg/ml. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

IgG1

N308

> 95% (SDS-PAGE)

Purified by Protein A affinity chromatography.

0.1 mg

WB, FCM, IP

PBS solution with 15 mM sodium azide.

Shipped within 5-12 working days.

Store at 2-8°C. Do not freeze.

No

O43561

27040

LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36

Antibody anti-LAT

RUO

Concentration: 1 mg/ml - 

Descripción

The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.

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LAT antibody

Required for TCR(T-cell antigen receptor)-and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3(low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1(high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

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