Linker For Activation of T-Cell (LAT) Antibody
338€ (0.1 mg)
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Name
Linker For Activation of T-Cell (LAT) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140111
Tested Applications
WB, FCM, IP
Description
LAT Antibody is a Mouse Monoclonal against LAT.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Linker For Activation of T-Cell (LAT) Immunogen: Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of Human LAT. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1-2 μg/ml, FCM: 1-4 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | N308 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | O43561 |
| Gene ID | 27040 |
| Alias | LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36 |
| Background | Antibody anti-LAT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.