Leukocyte Elastase Inhibitor (SERPINB1) Antibody
195€ (20 µl)
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935106861
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name
Leukocyte Elastase Inhibitor (SERPINB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx004779
tested applications
ELISA, WB, IHC, IF/ICC
Description
SERPINB1 Antibody is a Rabbit Polyclonal antibody against SERPINB1. The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte Elastase Inhibitor (SERPINB1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30740 |
| Gene ID | 1992 |
| NCBI Accession | NP_109591.1 |
| Alias | EI,LEI,PI2,MNEI,PI-2,HEL57,M/NEI,ELANH2,HEL-S-27,Leukocyte elastase inhibitor,Monocyte/neutrophil elastase inhibitor,Peptidase inhibitor 2,Serpin B1 |
| Background | Antibody anti-SERPINB1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
SERPINB1, also known as leukocyte elastase inhibitor or monocyte neutrophil elastase inhibitor, is a member of the serine protease inhibitor (SERPIN) family. The SERPIN superfamily is one of the largest and most diverse groups of protease inhibitors, playing a crucial role in regulating various physiological processes, including inflammation, apoptosis, and immune responses. Unlike many SERPINs that inhibit proteases through a suicide substrate-like mechanism involving the formation of a covalent complex, SERPINB1 acts primarily in the intracellular environment to protect cells from protease-mediated damage. SERPINB1 is encoded by the SERPINB1 gene located on chromosome 6p25 in humans. This gene belongs to the SERPINB clade, which is a subgroup of the SERPIN family predominantly found in the cytoplasm rather than being secreted
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