Leukocyte Elastase Inhibitor (SERPINB1) Antibody

Name: Leukocyte Elastase Inhibitor (SERPINB1) Antibody
Brand: Abbexa
SKU: abx004779
Price: 195 EUR
Availability: OnlineOnly

Este producto es parte de SERPINB1 - serpin family B member 1

Pida mas información

935106861

info@markelab.com

Precio

195€ (20 µl)

Antibody anti-SERPINB1

proveedor

Abbexa

reference

abx004779

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

SERPINB1 Antibody is a Rabbit Polyclonal antibody against SERPINB1. The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.

Background

SERPINB1, also known as leukocyte elastase inhibitor or monocyte neutrophil elastase inhibitor, is a member of the serine protease inhibitor (SERPIN) family. The SERPIN superfamily is one of the largest and most diverse groups of protease inhibitors, playing a crucial role in regulating various physiological processes, including inflammation, apoptosis, and immune responses. Unlike many SERPINs that inhibit proteases through a suicide substrate-like mechanism involving the formation of a covalent complex, SERPINB1 acts primarily in the intracellular environment to protect cells from protease-mediated damage. SERPINB1 is encoded by the SERPINB1 gene located on chromosome 6p25 in humans. This gene belongs to the SERPINB clade, which is a subgroup of the SERPIN family predominantly found in the cytoplasm rather than being secreted

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse, Rat

immunogen target

Leukocyte Elastase Inhibitor (SERPINB1)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB, IHC, IF/ICC

purification

Purified by affinity chromatography.

recommended dilution

ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.

size 1

20 µl

size 2

100 µl

size 3

2 × 100 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

SERPINB1

dry ice

availability

Shipped within 5-10 working days.

alias

EI,LEI,PI2,MNEI,PI-2,HEL57,M/NEI,ELANH2,HEL-S-27,Leukocyte elastase inhibitor,Monocyte/neutrophil elastase inhibitor,Peptidase inhibitor 2,Serpin B1

uniprot id

https://www.uniprot.org/uniprotkb/P30740

gene id

https://www.ncbi.nlm.nih.gov/gene/1992

NCBI accession

NP_109591.1

note

Concentration: > 0.2 mg/ml -

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proveedor

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reference

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reactivity

human

status

RUO

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