Leucine Rich Repeats And Immunoglobulin Like Domains Protein 3 (LRIG3) Antibody
299€ (100 µl)
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935106861
info@markelab.com
name
Leucine Rich Repeats And Immunoglobulin Like Domains Protein 3 (LRIG3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104731
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Leucine Rich Repeats And Immunoglobulin Like Domains Protein 3 (LRIG3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeats And Immunoglobulin Like Domains Protein 3 (LRIG3) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6P1C6 |
| Alias | LIG3,LIG-3 |
| Background | Antibody anti-LRIG3 |
| Status | RUO |
Descripción
LRIG3 is another member of the LRIG family, with structural domains similar to LRIG1 and LRIG2. It is widely expressed in neural tissues, the vascular system, and other organs, where it influences cell signaling, development, and tissue organization. LRIG3 is thought to play a role in neuronal development by regulating axon guidance and synaptic plasticity. LRIG3 interacts with RTKs and extracellular matrix proteins, modulating signaling pathways related to growth and differentiation. LRIG3 is also involved in vascular remodeling and angiogenesis. Dysregulation of LRIG3 has been linked to congenital malformations and vascular diseases, as well as certain cancers, where it can promote or suppress tumorigenesis depending on the context. Further research is needed to clarify its exact roles in health and disease.
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