Leucine-Rich Repeat-Containing Protein 7 (LRRC7) Antibody

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 7 (LRRC7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx146200
tested applications
ELISA, WB, IHC

Description

LRRC7 Antibody is a Rabbit Polyclonal against LRRC7.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Leucine-Rich Repeat-Containing Protein 7 (LRRC7)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC128989
Alias
Densin-18,Densin,Protein LAP1,KIAA1365, LAP1
Background
Antibody anti-LRRC7
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

LRRC7, also known as Densin-180, is a postsynaptic scaffolding protein enriched in the brain, where it regulates synaptic organization, signaling, and plasticity. It interacts with key proteins such as PSD-95, CaMKII, and actin regulators to stabilize and organize the postsynaptic density (PSD) at excitatory synapses. LRRC7 plays an essential role in dendritic spine maturation, synaptic strength, and calcium signaling, contributing to processes like learning, memory, and neuronal development. It is particularly abundant in regions like the hippocampus and cortex, where synaptic plasticity is critical. Dysregulation or mutations in LRRC7 are associated with neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders (ASD), due to impaired synaptic connectivity and function. Knockout studies in mice reveal altered dendritic spine morphology, impaired synaptic transmission, and deficits in learning and memory, highlighting its essential role in maintaining synaptic structure and cognitive function.
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