Leucine-Rich Repeat-Containing Protein 7 (LRRC7) Antibody
357.5€ (100 µg)
357.5€ (100 µg)
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935106861
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name
Leucine-Rich Repeat-Containing Protein 7 (LRRC7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx146200
tested applications
ELISA, WB, IHC
Descripción del producto
LRRC7 Antibody is a Rabbit Polyclonal against LRRC7.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| NCBI Accession | BC128989 |
| Alias | Densin-18,Densin,Protein LAP1,KIAA1365, LAP1 |
| Availability | Shipped within 7-15 working days. |
| Background | Antibody anti-LRRC7 |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Lyophilized |
| Host | Rabbit |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 7 (LRRC7) |
| Isotype | IgG |
| Name | Leucine-Rich Repeat-Containing Protein 7 (LRRC7) Antibody |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
| Price | 357.5 |
| Provider | Abbexa |
| Purification | Purified by antigen affinity column chromatography. |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx146200 |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Status | RUO |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB, IHC |
Descripcion del producto en español
Background en español
LRRC7, also known as Densin-180, is a postsynaptic scaffolding protein enriched in the brain, where it regulates synaptic organization, signaling, and plasticity. It interacts with key proteins such as PSD-95, CaMKII, and actin regulators to stabilize and organize the postsynaptic density (PSD) at excitatory synapses. LRRC7 plays an essential role in dendritic spine maturation, synaptic strength, and calcium signaling, contributing to processes like learning, memory, and neuronal development. It is particularly abundant in regions like the hippocampus and cortex, where synaptic plasticity is critical. Dysregulation or mutations in LRRC7 are associated with neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders (ASD), due to impaired synaptic connectivity and function. Knockout studies in mice reveal altered dendritic spine morphology, impaired synaptic transmission, and deficits in learning and memory, highlighting its essential role in maintaining synaptic structure and cognitive function.
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