Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122828
tested applications
ELISA, WB, IHC

Description

Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody is a rabbit polyclonal antibody against Human LRRC56 protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Leucine-Rich Repeat-Containing Protein 56 (LRRC56)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
BC016439
Alias
CILD39,DNAAF12,oda8
Background
Antibody anti-LRRC56
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

LRRC56 is a leucine-rich repeat-containing protein that functions as a critical regulator of cilia motility by facilitating the assembly of axonemal dynein arms, which are required for the beating of motile cilia. It localizes to the ciliary structure and interacts with proteins involved in dynein arm assembly and transport, enabling the proper function of motile cilia in tissues such as respiratory epithelium, brain ependyma, and reproductive organs. LRRC56 is essential for the coordinated beating of cilia, contributing to mucus clearance, fluid movement, and sperm motility. Mutations in LRRC56 are associated with primary ciliary dyskinesia (PCD), a condition characterized by chronic respiratory infections, reduced fertility, and hydrocephalus due to defective ciliary motility. Knockout studies reveal disrupted dynein arm assembly, immotile cilia, and impaired fluid movement, highlighting its critical role in ciliary function and the maintenance of tissue homeostasis.
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