Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody
357.5€ (100 µg)
357.5€ (100 µg)
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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122828
tested applications
ELISA, WB, IHC
Descripción del producto
Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody is a rabbit polyclonal antibody against Human LRRC56 protein.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| NCBI Accession | BC016439 |
| Alias | CILD39,DNAAF12,oda8 |
| Availability | Shipped within 7-15 working days. |
| Background | Antibody anti-LRRC56 |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Lyophilized |
| Host | Rabbit |
| Immunogen Target | Leucine-Rich Repeat-Containing Protein 56 (LRRC56) |
| Isotype | IgG |
| Name | Leucine-Rich Repeat-Containing Protein 56 (LRRC56) Antibody |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
| Price | 357.5 |
| Provider | Abbexa |
| Purification | Purified by antigen affinity column chromatography. |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx122828 |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Status | RUO |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB, IHC |
Descripcion del producto en español
Background en español
LRRC56 is a leucine-rich repeat-containing protein that functions as a critical regulator of cilia motility by facilitating the assembly of axonemal dynein arms, which are required for the beating of motile cilia. It localizes to the ciliary structure and interacts with proteins involved in dynein arm assembly and transport, enabling the proper function of motile cilia in tissues such as respiratory epithelium, brain ependyma, and reproductive organs. LRRC56 is essential for the coordinated beating of cilia, contributing to mucus clearance, fluid movement, and sperm motility. Mutations in LRRC56 are associated with primary ciliary dyskinesia (PCD), a condition characterized by chronic respiratory infections, reduced fertility, and hydrocephalus due to defective ciliary motility. Knockout studies reveal disrupted dynein arm assembly, immotile cilia, and impaired fluid movement, highlighting its critical role in ciliary function and the maintenance of tissue homeostasis.
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