Leucine Rich Repeat Containing Protein 4C (LRRC4C) Antibody (FITC)
169€ (20 µg)
169€ (20 µg)
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name
Leucine Rich Repeat Containing Protein 4C (LRRC4C) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx312055
Descripción del producto
LRRC4C Antibody (FITC) is a Rabbit Polyclonal against LRRC4C conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| OMIM | 608817 |
| Alias | LRRC4C, KIAA1580, NGL1,Netrin-G1 ligand ,NGL-1 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-LRRC4C |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 57689 |
| Host | Rabbit |
| Immunogen Target | Leucine Rich Repeat Containing Protein 4C (LRRC4C) |
| Isotype | IgG |
| Name | Leucine Rich Repeat Containing Protein 4C (LRRC4C) Antibody (FITC) |
| Price | 169 |
| Provider | Abbexa |
| Purification | Purified by Protein G. |
| Purity | > 95% |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx312055 |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| UniProt ID | Q9HCJ2 |
Descripcion del producto en español
Background en español
LRRC4C, or netrin-G ligand 4 (NGL-4), is a member of the leucine-rich repeat protein family involved in synaptic adhesion, axon guidance, and neural circuit formation. It binds to netrin-G proteins at synaptic junctions, facilitating the establishment and stabilization of excitatory synapses in the central nervous system. LRRC4C is highly expressed in the brain, particularly in regions responsible for cognitive and motor functions, where it regulates synaptic plasticity, neuronal migration, and dendritic spine development. Dysregulation of LRRC4C has been linked to neurodevelopmental disorders, such as autism spectrum disorders (ASD) and epilepsy, where disrupted synaptic organization and connectivity lead to impaired brain function. Knockout studies reveal defects in synaptic architecture, altered neuronal communication, and reduced cognitive performance, highlighting its critical role in synaptic development, neural circuit organization, and proper brain function.
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