Leucine Rich Repeat Containing Protein 4C (LRRC4C) Antibody
292.5€ (80 µl)
292.5€ (80 µl)
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935106861
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name
Leucine Rich Repeat Containing Protein 4C (LRRC4C) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030349
tested applications
ELISA, WB
Descripción del producto
NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM].
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | LRRC4C, KIAA1580, NGL1,Netrin-G1 ligand ,NGL-1 |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-LRRC4C |
| Buffer | PBS containing 0.09% sodium azide. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Dry Ice | No |
| Form | Liquid |
| Host | Rabbit |
| Immunogen Target | Leucine Rich Repeat Containing Protein 4C (LRRC4C) |
| Isotype | IgG |
| Name | Leucine Rich Repeat Containing Protein 4C (LRRC4C) Antibody |
| Price | 292.5 |
| Provider | Abbexa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx030349 |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA, WB |
| UniProt ID | Q9HCJ2 |
Descripcion del producto en español
Background en español
LRRC4C, or netrin-G ligand 4 (NGL-4), is a member of the leucine-rich repeat protein family involved in synaptic adhesion, axon guidance, and neural circuit formation. It binds to netrin-G proteins at synaptic junctions, facilitating the establishment and stabilization of excitatory synapses in the central nervous system. LRRC4C is highly expressed in the brain, particularly in regions responsible for cognitive and motor functions, where it regulates synaptic plasticity, neuronal migration, and dendritic spine development. Dysregulation of LRRC4C has been linked to neurodevelopmental disorders, such as autism spectrum disorders (ASD) and epilepsy, where disrupted synaptic organization and connectivity lead to impaired brain function. Knockout studies reveal defects in synaptic architecture, altered neuronal communication, and reduced cognitive performance, highlighting its critical role in synaptic development, neural circuit organization, and proper brain function.
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