Leucine-Rich Repeat-Containing Protein 48 (LRRC48) Antibody

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Leucine-Rich Repeat-Containing Protein 48 (LRRC48) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx036926
tested applications
ELISA, WB

Description

Rabbit Polyclonal against the LRRC48 protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Leucine-Rich Repeat-Containing Protein 48 (LRRC48)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
Dynein regulatory complex subunit 3,DRC3
Background
Antibody anti-DRC3
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

DRC3 is a component of the dynein regulatory complex (DRC), a critical structure within motile cilia and flagella that regulates the activity of axonemal dynein, ensuring proper ciliary beating and motility. DRC3 contributes to the stability and organization of the nexin-dynein regulatory complex, which links outer doublet microtubules and regulates dynein motor activity for coordinated ciliary motion. It is highly expressed in ciliated tissues, such as respiratory epithelium, reproductive organs, and brain ependyma, where it ensures efficient mucus clearance, fluid movement, and sperm motility. Mutations in DRC3 are associated with primary ciliary dyskinesia (PCD), a disorder characterized by impaired ciliary beating, leading to chronic respiratory infections, reduced fertility, and hydrocephalus due to defective fluid flow in the brain. Functional studies show that DRC3 is essential for maintaining ciliary structure and dynein regulation, as its loss causes abnormal ciliary waveform, reduced beat frequency, and impaired motility, highlighting its crucial role in the regulation of ciliary function and cellular homeostasis.
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