Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody (Biotin)
169€ (20 µg)
169€ (20 µg)
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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx306924
tested applications
ELISA
Descripción del producto
LRRC32 Antibody (Biotin) is a Rabbit Polyclonal against LRRC32 conjugated to Biotin.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| OMIM | 137207 |
| Alias | Garpin,Transforming growth factor beta activator LRRC32,Glycoprotein A repetitions predominant,D11S833E |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-LRRC32 |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 2615 |
| Host | Rabbit |
| Immunogen Target | Leucine Rich Repeat Containing Protein 32 (LRRC32) |
| Isotype | IgG |
| Name | Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody (Biotin) |
| Price | 169 |
| Provider | Abbexa |
| Purification | Purified by Protein G. |
| Purity | > 95% |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx306924 |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Tested Applications | ELISA |
| UniProt ID | Q14392 |
Descripcion del producto en español
Background en español
LRRC32, also known as glycoprotein A repetitions predominant (GARP), is a membrane protein highly expressed on regulatory T cells (Tregs) and platelets where it plays a critical role in regulating immune tolerance it acts as a receptor for latent TGF-β (transforming growth factor-beta) facilitating its activation and release on the cell surface LRRC32 is crucial for maintaining Treg function and suppressing excessive immune responses studies indicate its involvement in autoimmunity cancer and inflammation where dysregulation of LRRC32-mediated TGF-β signaling contributes to disease progression its role in tumor immunity is particularly notable as it enables tumors to evade immune surveillance by promoting an immunosuppressive microenvironment ongoing research is focused on targeting LRRC32 to modulate Treg activity in diseases such as cancer and autoimmune disorders making it a promising therapeutic candidate
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