Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody

299€ (100 µl)
Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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299€ (100 µl)

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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx104289
tested applications
WB, IHC, IF/ICC

Descripción del producto

Polyclonal Antibody to Leucine Rich Repeat Containing Protein 32 (LRRC32).

Documents del producto

Instrucciones
Data sheet
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Especificaciones del producto

AliasGarpin,Transforming growth factor beta activator LRRC32,Glycoprotein A repetitions predominant,D11S833E
AvailabilityShipped within 5-7 working days.
BackgroundAntibody anti-LRRC32
Buffer0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
CategoryPrimary Antibodies
ClonalityPolyclonal
ConjugationUnconjugated
Dry IceNo
FormLiquid
HostRabbit
Immunogen TargetLeucine Rich Repeat Containing Protein 32 (LRRC32)
NameLeucine Rich Repeat Containing Protein 32 (LRRC32) Antibody
Price299
ProviderAbbexa
PurificationPurified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
ReactivityMouse
Recommended DilutionWB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Referenceabx104289
Size 1100 µl
Size 2200 µl
Size 31 ml
StatusRUO
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Tested ApplicationsWB, IHC, IF/ICC

Descripcion del producto en español

Background en español

LRRC32, also known as glycoprotein A repetitions predominant (GARP), is a membrane protein highly expressed on regulatory T cells (Tregs) and platelets where it plays a critical role in regulating immune tolerance it acts as a receptor for latent TGF-β (transforming growth factor-beta) facilitating its activation and release on the cell surface LRRC32 is crucial for maintaining Treg function and suppressing excessive immune responses studies indicate its involvement in autoimmunity cancer and inflammation where dysregulation of LRRC32-mediated TGF-β signaling contributes to disease progression its role in tumor immunity is particularly notable as it enables tumors to evade immune surveillance by promoting an immunosuppressive microenvironment ongoing research is focused on targeting LRRC32 to modulate Treg activity in diseases such as cancer and autoimmune disorders making it a promising therapeutic candidate

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