Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody (APC)
793€ (100 tests)
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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx270752
tested applications
FCM
Description
Leucine Rich Repeat Containing Protein 32 (LRRC32) Antibody (APC) is a Rabbit Polyclonal Antibody conjugated to APC against Leucine Rich Repeat Containing Protein 32 (LRRC32) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat Containing Protein 32 (LRRC32) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | APC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | Garpin,Transforming growth factor beta activator LRRC32,Glycoprotein A repetitions predominant,D11S833E |
| Background | Antibody anti-LRRC32 |
| Status | RUO |
Descripción
LRRC32, also known as glycoprotein A repetitions predominant (GARP), is a membrane protein highly expressed on regulatory T cells (Tregs) and platelets where it plays a critical role in regulating immune tolerance it acts as a receptor for latent TGF-β (transforming growth factor-beta) facilitating its activation and release on the cell surface LRRC32 is crucial for maintaining Treg function and suppressing excessive immune responses studies indicate its involvement in autoimmunity cancer and inflammation where dysregulation of LRRC32-mediated TGF-β signaling contributes to disease progression its role in tumor immunity is particularly notable as it enables tumors to evade immune surveillance by promoting an immunosuppressive microenvironment ongoing research is focused on targeting LRRC32 to modulate Treg activity in diseases such as cancer and autoimmune disorders making it a promising therapeutic candidate
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