Leucine Rich Repeat Containing Protein 15 (LRRC15) Antibody (FITC)
169€ (20 µg)
169€ (20 µg)
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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 15 (LRRC15) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx308817
Descripción del producto
LRRC15 Antibody (FITC) is a Rabbit Polyclonal against LRRC15 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| NCBI Accession | NP_001128529.2, NM_001135057.2, NP_570843.2, NM_130830.4 |
| Alias | LIBLeucine-rich repeat protein induced by beta-amyloid homolog ,hLib |
| Availability | Shipped within 5-10 working days. |
| Background | Antibody anti-LRRC15 |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Category | Primary Antibodies |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Dry Ice | No |
| Form | Liquid |
| Gene ID | 131578 |
| Host | Rabbit |
| Immunogen Target | Leucine Rich Repeat Containing Protein 15 (LRRC15) |
| Isotype | IgG |
| Name | Leucine Rich Repeat Containing Protein 15 (LRRC15) Antibody (FITC) |
| Note | Concentration: 0.25 mg/ml - |
| Price | 169 |
| Provider | Abbexa |
| Purification | Purified by Protein G. |
| Purity | > 95% |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Reference | abx308817 |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Status | RUO |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| UniProt ID | Q8TF66 |
Descripcion del producto en español
Background en español
LRRC15 is a collagen-binding protein with a significant role in regulating extracellular matrix (ECM) remodeling and cell-matrix interactions it is widely expressed in stromal cells and tumor-associated fibroblasts where it participates in modulating cell adhesion and migration particularly in cancer and wound healing contexts LRRC15 has been identified as a critical component of the tumor microenvironment facilitating tumor progression and metastasis by influencing ECM organization and stiffness it is also involved in immune modulation through its interactions with immune cell receptors recent studies indicate its expression is upregulated in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis implicating it in pathological ECM deposition and remodeling LRRC15's potential as a therapeutic target is being explored particularly in oncology where its expression correlates with resistance to immune checkpoint inhibitors and poor prognosis in several cancers ongoing research aims to clarify its regulatory mechanisms in ECM biology and its cross-talk with other signaling pathways driving tissue repair and fibrosis
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