Leucine Rich Repeat Containing Protein 15 (LRRC15) Antibody

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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357.5€ (100 µg)

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935106861
info@markelab.com
name
Leucine Rich Repeat Containing Protein 15 (LRRC15) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037098
tested applications
ELISA, WB, IHC

Description

Rabbit Polyclonal against the LRRC15 protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Leucine Rich Repeat Containing Protein 15 (LRRC15)
Host
Rabbit
Reactivity
Human
Recommended Dilution
ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by antigen affinity column chromatography.
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized
Tested Applications
ELISA, WB, IHC
Buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
Availability
Shipped within 7-15 working days.
Storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q8TF66
Gene ID
131578
Alias
LIBLeucine-rich repeat protein induced by beta-amyloid homolog ,hLib
Background
Antibody anti-LRRC15
Status
RUO
Note
Concentration: Lyophilized form: Not applicable.  After reconstitution: 1 mg/ml. -

Descripción

LRRC15 is a collagen-binding protein with a significant role in regulating extracellular matrix (ECM) remodeling and cell-matrix interactions it is widely expressed in stromal cells and tumor-associated fibroblasts where it participates in modulating cell adhesion and migration particularly in cancer and wound healing contexts LRRC15 has been identified as a critical component of the tumor microenvironment facilitating tumor progression and metastasis by influencing ECM organization and stiffness it is also involved in immune modulation through its interactions with immune cell receptors recent studies indicate its expression is upregulated in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis implicating it in pathological ECM deposition and remodeling LRRC15's potential as a therapeutic target is being explored particularly in oncology where its expression correlates with resistance to immune checkpoint inhibitors and poor prognosis in several cancers ongoing research aims to clarify its regulatory mechanisms in ECM biology and its cross-talk with other signaling pathways driving tissue repair and fibrosis

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