Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) Antibody (FITC)
169€ (20 µg)
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Name
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx343731
Description
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human LGR5.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) Immunogen: Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 5 protein (241-352 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75473 |
| Gene ID | 8549 |
| OMIM | 606667 |
| Alias | LGR5,GPR49,FEX,GPR67,orphan G protein-coupled receptor HG38,leucine-rich repeat-containing G protein-coupled receptor 5,leucine-rich repeat containing G protein-coupled receptor 5 |
| Background | Antibody anti-LGR5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
LGR5 is another member of the LGR family, closely associated with stem cell maintenance and tissue regeneration. It is highly expressed in adult stem cells of various tissues, including the intestines, hair follicles, and the mammary gland. LGR5 is a key player in regulating Wnt signaling, a pathway that controls stem cell proliferation, self-renewal, and differentiation. In the intestines, LGR5+ stem cells are essential for maintaining the intestinal epithelium and enabling tissue regeneration after injury. LGR5 is also involved in the formation and progression of tumors, particularly in colorectal cancer, where LGR5+ cells contribute to tumor initiation and metastasis. Research into LGR5 is actively exploring its role as a biomarker for cancer and its potential as a target for cancer therapies that aim to disrupt the Wnt signaling pathway and inhibit tumor growth. Additionally, LGR5 is being studied for its role in tissue repair and stem cell therapies.
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