Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibody
292.5€ (80 µl)
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Name
Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx031684
Tested Applications
ELISA, WB, IHC, FCM
Description
LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Immunogen: KLH-conjugated synthetic peptide between 443-473 amino acids from the Central region of human LGR5 (GPR49). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/500, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 100 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75473 |
| NCBI Accession | NP_001264155.1, NP_003658.1 |
| Alias | LGR5,GPR49,FEX,GPR67,orphan G protein-coupled receptor HG38,leucine-rich repeat-containing G protein-coupled receptor 5,leucine-rich repeat containing G protein-coupled receptor 5 |
| Background | Antibody anti-LGR5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
LGR5 is another member of the LGR family, closely associated with stem cell maintenance and tissue regeneration. It is highly expressed in adult stem cells of various tissues, including the intestines, hair follicles, and the mammary gland. LGR5 is a key player in regulating Wnt signaling, a pathway that controls stem cell proliferation, self-renewal, and differentiation. In the intestines, LGR5+ stem cells are essential for maintaining the intestinal epithelium and enabling tissue regeneration after injury. LGR5 is also involved in the formation and progression of tumors, particularly in colorectal cancer, where LGR5+ cells contribute to tumor initiation and metastasis. Research into LGR5 is actively exploring its role as a biomarker for cancer and its potential as a target for cancer therapies that aim to disrupt the Wnt signaling pathway and inhibit tumor growth. Additionally, LGR5 is being studied for its role in tissue repair and stem cell therapies.
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