Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibody
292.5€ (80 µl)
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935106861
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name
Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031684
tested applications
ELISA, WB, IHC, FCM
Description
LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine Rich Repeat Containing G Protein-Coupled Receptor 5 (LGR5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/500, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75473 |
| NCBI Accession | NP_001264155.1, NP_003658.1 |
| Alias | LGR5,GPR49,FEX,GPR67,orphan G protein-coupled receptor HG38,leucine-rich repeat-containing G protein-coupled receptor 5,leucine-rich repeat containing G protein-coupled receptor 5 |
| Background | Antibody anti-LGR5 |
| Status | RUO |
Descripción
LGR5 is another member of the LGR family, closely associated with stem cell maintenance and tissue regeneration. It is highly expressed in adult stem cells of various tissues, including the intestines, hair follicles, and the mammary gland. LGR5 is a key player in regulating Wnt signaling, a pathway that controls stem cell proliferation, self-renewal, and differentiation. In the intestines, LGR5+ stem cells are essential for maintaining the intestinal epithelium and enabling tissue regeneration after injury. LGR5 is also involved in the formation and progression of tumors, particularly in colorectal cancer, where LGR5+ cells contribute to tumor initiation and metastasis. Research into LGR5 is actively exploring its role as a biomarker for cancer and its potential as a target for cancer therapies that aim to disrupt the Wnt signaling pathway and inhibit tumor growth. Additionally, LGR5 is being studied for its role in tissue repair and stem cell therapies.
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Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins(RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
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