Leucine-Rich Repeat And Fibronectin Type-III Domain-Containing Protein 2 (LRFN2) Antibody
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Description
LRFN2 promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A. May play a role in redistributing DLG4 to the cell periphery (By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeat And Fibronectin Type-III Domain-Containing Protein 2 (LRFN2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9ULH4 |
| Alias | SALM1,FIGLER2,KIAA1246,Synaptic adhesion-like molecule 1 |
| Background | Antibody anti-LRFN2 |
| Status | RUO |
Descripción
LRFN2 is highly expressed in the CNS, particularly in excitatory neurons, where it regulates synaptic development and neurotransmitter release. Its LRR and FNIII domains mediate interactions with synaptic proteins to influence synapse formation and plasticity. LRFN2 is implicated in modulating neuronal activity and maintaining synaptic balance. Dysregulation of LRFN2 is linked to cognitive impairments and psychiatric disorders, including schizophrenia and anxiety.
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