Leptin Receptor (LEPR) Antibody (Biotin)
351€ (200 µl)
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Name
Leptin Receptor (LEPR) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx274443
Tested Applications
WB, IHC, IF/ICC
Description
Leptin Receptor (LEPR) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Leptin Receptor (LEPR).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Leptin Receptor (LEPR) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | OBR,OB-R,CD295,LEP-R,LEPRD,HuB219,OB receptor |
| Background | Antibody anti-LEPR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The leptin receptor (LEPR) is a cell surface receptor that plays a central role in energy homeostasis, metabolism, and body weight regulation. LEPR is the receptor for leptin, a hormone primarily secreted by adipose (fat) tissue that signals satiety and energy sufficiency to the brain. Leptin and its receptor are fundamental to regulating food intake, body weight, and energy expenditure. When leptin binds to LEPR, it triggers a cascade of intracellular signals that inform the central nervous system about the body's energy reserves, particularly in the hypothalamus, which then influences appetite suppression, metabolism, and other endocrine functions. LEPR is essential in maintaining homeostatic control over body mass, as dysregulation or mutations in the leptin receptor pathway can lead to obesity, diabetes, and metabolic syndrome.
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