Leptin Receptor (LEPR) Antibody
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935106861
info@markelab.com
Precio
292.5€ (80 µl)
Antibody anti-LEPR
proveedor
Abbexareference
abx032703Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR). LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.
Background
The leptin receptor (LEPR) is a cell surface receptor that plays a central role in energy homeostasis, metabolism, and body weight regulation. LEPR is the receptor for leptin, a hormone primarily secreted by adipose (fat) tissue that signals satiety and energy sufficiency to the brain. Leptin and its receptor are fundamental to regulating food intake, body weight, and energy expenditure. When leptin binds to LEPR, it triggers a cascade of intracellular signals that inform the central nervous system about the body's energy reserves, particularly in the hypothalamus, which then influences appetite suppression, metabolism, and other endocrine functions. LEPR is essential in maintaining homeostatic control over body mass, as dysregulation or mutations in the leptin receptor pathway can lead to obesity, diabetes, and metabolic syndrome.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Leptin Receptor (LEPR)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, FCM
purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
recommended dilution
WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
LEPR
dry ice
No
availability
Shipped within 5-10 working days.
alias
OBR,OB-R,CD295,LEP-R,LEPRD,HuB219,OB receptor
uniprot id
NCBI accession
NP_001003679.1, NP_001003680.1, NP_001185616.1, NP_001185617.1, NP_001185618.1, NP_002294.2
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