Leptin (LEP) Antibody
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Description
Leptin (LEP) is an adipocyte-secreted protein that regulates body fat and endocrine functions. Leptin is similar to the mouse obesity protein encoded by the obese gene (ob). In mouse studies, mutations in this gene are linked to severe and morbid obesity.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Leptin (LEP) Immunogen: KLH-conjugated synthetic peptide between 134-166 amino acids from the C-terminal region of human Leptin (LEP). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 18.6 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41159 |
| Alias | OB,OBS,LEPD,Obese protein,Obesity factor |
| Background | Antibody anti-LEP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Leptin ( LEP) is an adipokine predominantly produced by adipocytes that plays a key role in regulating energy balance, appetite, and metabolism by acting on the hypothalamus Leptin signals through its receptor (LEPR) to suppress food intake and promote energy expenditure, maintaining body weight homeostasis Circulating leptin levels are proportional to fat mass, with increased levels observed in obesity due to leptin resistance Dysregulation of leptin signaling is associated with metabolic syndrome, type 2 diabetes, and cardiovascular diseases Leptin also exerts immunomodulatory functions, influencing the activity of T cells, macrophages, and other immune cells to enhance pro-inflammatory responses It is implicated in autoimmune diseases, including rheumatoid arthritis and lupus, where elevated leptin promotes chronic inflammation Leptin’s role extends to bone metabolism, reproductive function, and wound healing, highlighting its pleiotropic effects in energy homeostasis and systemic physiology
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Mouse/Rat Leptin ELISA is suited for measuring Leptin in mouse and rat serum for scientific purposes. It utilizes two different specific high affinity polyclonal antibodies for this protein.
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The ELISA E07 is intended to be used for quantitative measurement of human Leptin in human serum and plasma samples. This enzyme immunoassay kit is suited for measuring human leptin in serum or plasma, and conditioned adipocyte culture media for scientific and diagnostic purposes. Measuring leptin in anorectic or cachectic patients, young children or in specimen other than serum, such as urine, cerebrospinal fluid, and certain cell culture media, is also possible with this kit.
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This immunoassay kit enables measurement of human leptin in serum or plasma for diagnostic purposes. The test kit is also suitable for measuring exceptionally low concentrations of leptin, for example in samples from patients with anorexia or cachexia and from children. For the standard application of measurement in serum or plasma samples from individuals with normal weight (expected levels between 1 and 100 ng/mL leptin), we recommend our Leptin ELISA product number E07.
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