Leptin amino terminal Antibody
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Description
Leptin amino terminal Antibody is a Rabbit polyclonal antibody for proteins and bioactive peptides against Leptin amino terminal.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Leptin amino terminal Immunogen: Immunogen is derived from the n-terminal (residues 1-24). |
| Host | Rabbit |
| Recommended Dilution | Validated in IHC-F and ICC. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Neat. |
| Size 1 | 100 µl |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | Buffer contains no preservative. |
| Availability | Shipped within 10-20 working days. |
| Storage | Store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | OB,OBS,LEPD,Obese protein,Obesity factor |
| Background | Antibody anti-LEP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Leptin ( LEP) is an adipokine predominantly produced by adipocytes that plays a key role in regulating energy balance, appetite, and metabolism by acting on the hypothalamus Leptin signals through its receptor (LEPR) to suppress food intake and promote energy expenditure, maintaining body weight homeostasis Circulating leptin levels are proportional to fat mass, with increased levels observed in obesity due to leptin resistance Dysregulation of leptin signaling is associated with metabolic syndrome, type 2 diabetes, and cardiovascular diseases Leptin also exerts immunomodulatory functions, influencing the activity of T cells, macrophages, and other immune cells to enhance pro-inflammatory responses It is implicated in autoimmune diseases, including rheumatoid arthritis and lupus, where elevated leptin promotes chronic inflammation Leptin’s role extends to bone metabolism, reproductive function, and wound healing, highlighting its pleiotropic effects in energy homeostasis and systemic physiology
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