Legionella pneumophila LPS Antibody
1118€ (1 mg)
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name
Legionella pneumophila LPS Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx024036
tested applications
ELISA, LF
Description
Legionella pneumophila LPS Antibody is a Mouse Monoclonal against Legionella pneumophila LPS Serotype 1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Legionella pneumophila LPS |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 |
| Clone ID | M161 |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified from cell culture by Protein A Chromatography. |
| Size 1 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, LF |
| Buffer | 12 mM Phosphate Buffered Saline, pH 7.4, containing 0.09% Sodium Azide. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store between 2-8°C upon receipt. |
| Dry Ice | No |
| Alias | LPS |
| Background | Antibody anti-LPS |
| Status | RUO |
| Note | Concentration: 3.7 mg/ml - |
Descripción
Lipopolysaccharides (LPS) are large molecules found in the outer membrane of Gram-negative bacteria, playing a crucial role in the structural integrity of bacterial cells and acting as a potent activator of the immune system. Composed of lipid A, a core oligosaccharide, and an O-antigen polysaccharide, LPS is a critical factor in bacterial pathogenicity. Lipid A is the bioactive component that triggers immune responses by binding to the Toll-like receptor 4 (TLR4) complex on immune cells, leading to the activation of nuclear factor-kappa B (NF-κB) and the release of pro-inflammatory cytokines such as IL-6 and TNF-alpha. While LPS is essential for host defense, its excessive activation can result in septic shock, characterized by systemic inflammation, organ failure, and high mortality. Therapeutic strategies targeting LPS-TLR4 signaling pathways are being explored to manage sepsis and other inflammatory conditions.
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