Large Neutral Amino Acid Transporter / LAT1 (CD98) Antibody (FITC)

Este producto es parte de SLC7A5 - solute carrier family 7 member 5
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364€ (100 tests)

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935106861
info@markelab.com
name
Large Neutral Amino Acid Transporter / LAT1 (CD98) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx139879
tested applications
FCM

Description

CD98 Antibody is a Mouse Monoclonal against CD98.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Large Neutral Amino Acid Transporter / LAT1 (CD98)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 20 µl/100 µl of whole blood or 106 cells. Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. The content of a vial (2 ml) is sufficient for 100 tests.
Clonality
Monoclonal
Conjugation
FITC
Isotype
IgG1
Clone ID
E758
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
Q01650
Gene ID
8140
Alias
Large neutral amino acids transporter small subunit 1,4F2 light chain,E16,CD98,LAT1,4F2LC,MPE16,D16S469E,CD98 light chain,Integral membrane protein E16
Background
Antibody anti-SLC7A5
Status
RUO

Descripción

SLC7A5, also known as LAT1 (L-type amino acid transporter 1), is a transmembrane protein crucial for amino acid transport across the plasma membrane. It is part of the solute carrier family 7 (SLC7), specifically associated with the transport of large neutral amino acids (LNAAs) like leucine, isoleucine, valine, phenylalanine, and tryptophan, which are essential for various cellular functions. LAT1 is a high-affinity, sodium-independent transporter and functions as part of a heteromeric complex with SLC3A2 (4F2hc or CD98), which acts as a chaperone protein for the proper membrane localization and functionality of LAT1. SLC7A5 plays a significant role in cellular growth and proliferation, and it is highly expressed in rapidly dividing cells. It is abundant in tissues with high metabolic demands, such as the brain, placenta, and certain immune cells, as well as in many cancer cell types, where it facilitates the increased amino acid demand required for protein synthesis and tumor growth. LAT1 is also integral to the blood-brain barrier, as it enables the transport of essential amino acids into the brain, thereby impacting neurotransmitter synthesis.

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