L-Selectin / CD62L (SELL) Antibody
292.5€ (50 µl)
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935106861
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name
L-Selectin / CD62L (SELL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx033100
tested applications
ELISA, WB, IHC, FCM
Description
SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | L-Selectin / CD62L (SELL) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/2000, IHC-P: 1/10 - 1/50, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 50 µl |
| Size 2 | 200 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14151 |
| NCBI Accession | NP_000646.2 |
| Alias | TQ1,LAM1,LEU8,LNHR,LSEL,CD62L,LYAM1,PLNHR,LECAM1,L-selectin,CD62 antigen-like family member L,Leukocyte adhesion molecule 1,Leukocyte surface antigen Leu-8,Leukocyte-endothelial cell adhesion molecule 1 |
| Background | Antibody anti-SELL |
| Status | RUO |
Descripción
Selectin L (SELL), commonly known as L-selectin, is a cell adhesion molecule that belongs to the selectin family, which includes three primary members: L-selectin (SELL), E-selectin (SELE), and P-selectin (SELP). L-selectin plays a crucial role in immune surveillance and inflammatory responses, primarily facilitating the interaction between leukocytes (white blood cells) and endothelial cells. SELL is expressed constitutively on most leukocytes, including neutrophils, monocytes, T lymphocytes, B lymphocytes, and natural killer (NK) cells. It is essential for the initial steps of leukocyte extravasation, where leukocytes migrate from the bloodstream to peripheral tissues to respond to infection or injury. SELL mediates leukocyte rolling on the endothelium, an essential part of the immune cell recruitment cascade during inflammation and immune surveillance. It is involved in homing of lymphocytes to secondary lymphoid organs, such as lymph nodes, and facilitates the recruitment of leukocytes to sites of inflammation. SELL’s primary ligands include sialyl Lewis X (sLeX) and GlyCAM-1 (glycan-bearing cell adhesion molecule-1), which are expressed on endothelial cells. The role of L-selectin in trafficking leukocytes to lymphoid tissues is vital for maintaining immune homeostasis and responding to pathogens.
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