KIR3DL1 Protein
234€ (5 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
KIR3DL1 Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx261982
tested applications
SDS-PAGE
Description
KIR3DL1 is a recombinant protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | KIR3DL1 |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE and RP-HPLC) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P43629 |
| Alias | CD158 antigen-like family member E,HLA-BW4-specific inhibitory NK cell receptor,CD158E,NKAT3,NKB1Natural killer-associated transcript 3,KIR,NKB1,NKAT3,NKB1B,NKAT-3,CD158E1,KIR2DL5B,KIR3DL1/S1 |
| Background | Protein KIR3DL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Killer Cell Immunoglobulin-Like Receptor 3DL1 (KIR3DL1) is a member of the KIR family, expressed on natural killer (NK) cells and a subset of T lymphocytes, playing a critical role in modulating immune responses. This receptor binds specifically to HLA class I molecules, particularly HLA-B alleles with the Bw4 motif, allowing NK cells to recognize and monitor the health of target cells. When KIR3DL1 engages its ligand, it delivers inhibitory signals that suppress NK cell cytotoxic activity, thus maintaining immune homeostasis and preventing autoreactivity. Variations in KIR3DL1, including polymorphisms and expression levels, are associated with differential susceptibility to infectious diseases, cancer, and autoimmune conditions. Studies have also highlighted its significance in allogeneic hematopoietic stem cell transplantation, where KIR-HLA mismatches can influence graft-versus-leukemia effects and transplantation outcomes. By regulating NK cell activity, KIR3DL1 contributes to the delicate balance between immune surveillance and tolerance, making it a valuable target for therapeutic interventions in cancer immunotherapy and immune-mediated disorders.
Related Products
Human KIR3DL1 (Killer cell immunoglobulin-like receptor 3DL1) ELISA Kit
Ver Producto
anti- KIR3DL1 antibody
Receptor on natural killer(NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
Ver Producto