Killer Cell Lectin-Like Receptor Subfamily C, Member 2 Protein
234€ (2 µg)
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935106861
info@markelab.com
name
Killer Cell Lectin-Like Receptor Subfamily C, Member 2 Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx262536
tested applications
SDS-PAGE
Description
KLRC2 is a recombinant protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | KLRC2 |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P26717 |
| Alias | NKG2-C type II integral membrane protein,NKG2C,CD159c,NKG2-C,CD159 antigen-like family member C,NK cell receptor C,NKG2-C-activating NK receptor |
| Background | Protein KLRC2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Killer cell lectin like receptor C2 (KLRC2), commonly referred to as NKG2C, is an activating receptor expressed on NK cells and some T cells. Unlike KLRC1, KLRC2 interacts with HLA-E to initiate stimulatory signals that enhance cytotoxic responses and cytokine production. KLRC2 signaling is mediated through its association with the adaptor molecule DAP12, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) responsible for triggering downstream signaling cascades. This receptor is pivotal in the immune response against infected or transformed cells, particularly in conditions where HLA-E is overexpressed due to stress or infection. KLRC2 is also involved in adaptive immune responses, contributing to the expansion and memory-like properties of NK cells, especially during cytomegalovirus (CMV) infections. Targeting KLRC2 pathways is being explored to potentiate immune responses in infectious diseases and cancer therapies.
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