Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) Antibody (Biotin)
351€ (200 µl)
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935106861
info@markelab.com
name
Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx271405
tested applications
WB, IHC, IF/ICC
Description
Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD158 antigen-like family member K,Natural killer-associated transcript 4,NKAT-4,p70 natural killer cell receptor clone CL-5,3DL2,CD158K,NKAT4B,KIR-3DL2 |
| Background | Antibody anti-KIR3DL2 |
| Status | RUO |
Descripción
Killer Cell Immunoglobulin-Like Receptor 3DL2 (KIR3DL2) is a member of the KIR family of receptors expressed predominantly on natural killer (NK) cells and subsets of T cells, playing a significant role in immune system regulation and surveillance. This receptor specifically interacts with HLA class I molecules, with a preference for HLA-A3 and HLA-A11 alleles, delivering inhibitory signals that modulate NK cell cytotoxicity and cytokine production. KIR3DL2 polymorphisms and expression levels have been implicated in susceptibility to autoimmune diseases such as ankylosing spondylitis and certain infections, demonstrating its critical role in balancing immune activation and tolerance. Recent studies highlight the involvement of KIR3DL2 in cancer, particularly in Hodgkin’s lymphoma, where it may serve as a therapeutic target for novel immunotherapies. Through its inhibitory signaling and interaction with diverse HLA ligands, KIR3DL2 ensures immune homeostasis while also influencing outcomes in transplantation and disease progression.
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