Human Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) Protein
247€ (10 µg)
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935106861
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name
Human Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067653
tested applications
WB, SDS-PAGE
Description
Recombinant Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 3DL2 (KIR3DL2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 59.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro184-Glu435 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43630 |
| Alias | CD158 antigen-like family member K,Natural killer-associated transcript 4,NKAT-4,p70 natural killer cell receptor clone CL-5,3DL2,CD158K,NKAT4B,KIR-3DL2 |
| Background | Protein KIR3DL2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Killer Cell Immunoglobulin-Like Receptor 3DL2 (KIR3DL2) is a member of the KIR family of receptors expressed predominantly on natural killer (NK) cells and subsets of T cells, playing a significant role in immune system regulation and surveillance. This receptor specifically interacts with HLA class I molecules, with a preference for HLA-A3 and HLA-A11 alleles, delivering inhibitory signals that modulate NK cell cytotoxicity and cytokine production. KIR3DL2 polymorphisms and expression levels have been implicated in susceptibility to autoimmune diseases such as ankylosing spondylitis and certain infections, demonstrating its critical role in balancing immune activation and tolerance. Recent studies highlight the involvement of KIR3DL2 in cancer, particularly in Hodgkin’s lymphoma, where it may serve as a therapeutic target for novel immunotherapies. Through its inhibitory signaling and interaction with diverse HLA ligands, KIR3DL2 ensures immune homeostasis while also influencing outcomes in transplantation and disease progression.
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