Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Antibody (PE)
585€ (100 tests)
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935106861
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name
Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx270857
tested applications
FCM
Description
Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | CD158 antigen-like family member I,KKA3,KIR1D,Natural killer-associated transcript 8,NKAT8,CD158I,KIR412,NKAT-8,KIR-2DS4,P58 natural killer cell receptor clones CL-39/CL-17 |
| Background | Antibody anti-KIR2DS4 |
| Status | RUO |
Descripción
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) is part of the Killer-cell Immunoglobulin-like Receptor (KIR) family, which plays a central role in the immune system, specifically in regulating natural killer (NK) cells and certain T-cell functions. KIR2DS4 is one of the activating receptors in the KIR family and is particularly involved in identifying cells that may be infected, stressed, or tumorigenic. KIR receptors, including KIR2DS4, contribute to the immune system's adaptability through interactions with human leukocyte antigen (HLA) molecules, typically class I. However, unlike many KIR receptors that mediate inhibitory signals, KIR2DS4 is an activating receptor. It provides stimulatory signals that help NK cells become cytotoxic toward specific target cells. KIR genes, including KIR2DS4, are highly polymorphic, with substantial genetic variation between individuals, contributing to variations in immune response. KIR genes are clustered on chromosome 19, and their expression varies across different populations, impacting immune response diversity. This variation has implications for disease susceptibility, transplantation compatibility, and response to certain therapies.
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