Killer Cell Immunoglobulin Like Receptor 2DL5 (KIR2DL5) Antibody
286€ (100 µl)
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Name
Killer Cell Immunoglobulin Like Receptor 2DL5 (KIR2DL5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx128994
Tested Applications
IHC
Description
Killer Cell Immunoglobulin Like Receptor 2DL5 Antibody is a Rabbit Polyclonal against Killer Cell Immunoglobulin Like Receptor 2DL5.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Killer Cell Immunoglobulin Like Receptor 2DL5 (KIR2DL5) Immunogen: KIR2DL5 (His22-Ile375) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD158F,KIR2DL5,KIR2DL5.1,KIR2DL5.3 |
| Background | Antibody anti-KIR2DL5A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Killer cell immunoglobulin-like receptor 2DL5A (KIR2DL5A) is a member of the KIR family, which plays a crucial role in immune regulation, especially in natural killer (NK) cell and some T-cell activities. These receptors allow immune cells to differentiate between normal cells and those that may be infected, stressed, or malignant. KIR2DL5A, like other inhibitory KIR receptors, is known for its role in maintaining immune tolerance by providing inhibitory signals to prevent NK cells from attacking healthy tissues. This regulation is achieved through interactions with specific ligands, mainly human leukocyte antigen (HLA) class I molecules on target cells. However, the specific HLA ligands for KIR2DL5A remain under research, with some studies suggesting unique ligand interactions within this receptor subtype. KIR2DL5A is located on chromosome 19 within the KIR gene cluster, which exhibits considerable genetic diversity across individuals. This diversity allows NK cells to adapt to various pathogenic and environmental pressures. The polymorphic nature of KIR genes like KIR2DL5A contributes to variations in immune responses between individuals, which can influence susceptibility to infections, autoimmune diseases, and cancer.
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