Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody (Biotin)
377€ (200 µl)
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Name
Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx271402
Tested Applications
IHC
Description
Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Killer Cell Immunoglobulin Like Receptor 2DL3 (KIR2DL3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 200 µl |
| Size 2 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CD158 antigen-like family member B2,KIR-023GB,Killer inhibitory receptor cl 2-3,NKAT2a,NKAT2b,GL183,CD158b,KIR2DL |
| Background | Antibody anti-KIR2DL3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
KIR2DL3 is an inhibitory receptor that is part of the killer cell immunoglobulin-like receptor (KIR) family, which is primarily expressed on natural killer (NK) cells and some T-cell subsets. This receptor plays a pivotal role in immune surveillance and modulation by binding to specific HLA class I molecules, particularly HLA-C alleles, on potential target cells. KIR2DL3 recognizes HLA-C1 (characterized by an asparagine at position 80), which is different from HLA-C2 (lysine at position 80) recognized by related receptors like KIR2DL1. By binding to HLA-C1, KIR2DL3 sends inhibitory signals that regulate NK cell cytotoxicity, promoting immune tolerance and minimizing the risk of autoimmunity. The KIR genes, including KIR2DL3, are located on chromosome 19q13.4 in a highly polymorphic region known as the leukocyte receptor complex (LRC). Genetic variability within this complex, particularly in the KIR2DL3 and its HLA-C ligands, contributes to diversity in immune response among individuals. Variants in KIR2DL3 and other KIR genes are associated with differential susceptibility to diseases, including autoimmune disorders, viral infections, and cancers.
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