Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) Antibody (Biotin)
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Description
KIR2DL1 Antibody (Biotin) is a Rabbit Polyclonal against KIR2DL1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43626 |
| Gene ID | 3802 |
| Alias | CD158 antigen-like family member A,Natural killer-associated transcript 1,NKAT,NKAT1,p58.1,CD158A,KIR221,NKAT-1,KIR-K64,KIR2DL3, |
| Background | Antibody anti-KIR2DL1 |
| Status | RUO |
Descripción
Killer cell immunoglobulin-like receptors (KIRs) are a family of proteins primarily expressed on the surface of natural killer (NK) cells and some T-cell subsets, where they play a crucial role in the innate immune system. KIR2DL1, a member of this family, specifically recognizes certain human leukocyte antigen (HLA) class I molecules, allowing NK cells to monitor cellular health by detecting variations in HLA expression. KIR2DL1 is an inhibitory receptor, meaning that its engagement generally suppresses NK cell cytotoxic activity. The interaction between KIR2DL1 and HLA class I molecules is part of a broader system known as immune surveillance, where NK cells detect and respond to stress or infection signals on potential target cells, such as virally infected or transformed cells. KIRs are highly polymorphic and exhibit considerable variability among individuals. This diversity contributes to the versatility of NK cell responses, enhancing the immune system's adaptability. The genes encoding KIR proteins, including KIR2DL1, are located on chromosome 19q13.4 in the leukocyte receptor complex (LRC). KIR2DL1 recognizes HLA-C molecules, specifically those with the C2 epitope (HLA-C group 2), which consists of specific amino acid sequences.
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