Human Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx067647
Tested Applications
WB, SDS-PAGE
Description
Human Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: His22-Pro348 Tag: N-terminal His tag and GST tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 68.2 kDa Observed MW (SDS-PAGE): 70 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43626 |
| Alias | CD158 antigen-like family member A,Natural killer-associated transcript 1,NKAT,NKAT1,p58.1,CD158A,KIR221,NKAT-1,KIR-K64,KIR2DL3, |
| Background | Protein KIR2DL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Killer cell immunoglobulin-like receptors (KIRs) are a family of proteins primarily expressed on the surface of natural killer (NK) cells and some T-cell subsets, where they play a crucial role in the innate immune system. KIR2DL1, a member of this family, specifically recognizes certain human leukocyte antigen (HLA) class I molecules, allowing NK cells to monitor cellular health by detecting variations in HLA expression. KIR2DL1 is an inhibitory receptor, meaning that its engagement generally suppresses NK cell cytotoxic activity. The interaction between KIR2DL1 and HLA class I molecules is part of a broader system known as immune surveillance, where NK cells detect and respond to stress or infection signals on potential target cells, such as virally infected or transformed cells. KIRs are highly polymorphic and exhibit considerable variability among individuals. This diversity contributes to the versatility of NK cell responses, enhancing the immune system's adaptability. The genes encoding KIR proteins, including KIR2DL1, are located on chromosome 19q13.4 in the leukocyte receptor complex (LRC). KIR2DL1 recognizes HLA-C molecules, specifically those with the C2 epitope (HLA-C group 2), which consists of specific amino acid sequences.
Productos relacionados
Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) Antibody
KIR2DL1 Antibody is a Rabbit Polyclonal antibody against KIR2DL1. Killer cell immunoglobulin-like receptors (KIRs) are t…
Ver producto
Human Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) Protein
Human Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) is a recombinant Human protein expressed in E. coli.…
Ver producto
Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1) Antibody
Polyclonal Antibody to Killer Cell Immunoglobulin Like Receptor 2DL1 (KIR2DL1).…
Ver producto