Keratin, Type I Cytoskeletal 17 (KRT17) Antibody

Description

CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17.It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages.Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair.May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells".May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state.Modulates the function of TNF-alpha in the specific context of hair cycling.Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway.Involved in tissue repair.