Kelch-Like Protein 22 (KLHL22) Antibody

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Kelch-Like 22 (Drosophila) Antibody is a Rabbit Polyclonal antibody against Kelch-Like 22 (Drosophila).
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | Kelch-Like Protein 22 (KLHL22) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Antigen Affinity Chromatography. |
Size 1 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, WB |
Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q53GT1 |
Gene ID | 84861 |
NCBI Accession | NP_116164.2, NM_032775.3 |
Background | Antibody anti-KLHL22 |
Status | RUO |
Descripción
Related Products

KLHL22 antibody
Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint(SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
Ver Producto
Kelch-Like Protein 22 (KLHL22) Antibody
KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophilakelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.
Ver Producto
Kelch-Like Protein 22 (KLHL22) Antibody
Kelch-Like 22 (Drosophila) Antibody is a Rabbit Polyclonal antibody against Kelch-Like 22 (Drosophila).
Ver Producto