Karyopherin Alpha 3 (KPNA3) Antibody

Este producto es parte de KPNA - karyopherin subunit alpha
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312€ (60 µl)

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935106861
info@markelab.com
name
Karyopherin Alpha 3 (KPNA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005802
tested applications
IHC

Description

KPNA3 Antibody is a Rabbit Polyclonal Antibody against KPNA3.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Karyopherin Alpha 3 (KPNA3)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
60 µl
Size 2
120 µl
Size 3
200 µl
Form
Liquid
Tested Applications
IHC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O00505
Gene ID
3839
NCBI Accession
NP_002258.2
Alias
QIP2,Importin alpha Q2,Importin subunit alpha-4,SRP1,SRP4,IPOA4,SPG88; Hsrp1,SRP1gamma
Background
Antibody anti-KPNA3
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

KPNA3, or importin-α3, is another member of the importin-α family that mediates the nuclear import of cargo proteins with classical nuclear localization signals (NLS). It interacts with importin-β to form a complex that transports cargo proteins through the nuclear pore complex (NPC). KPNA3 is expressed in various tissues and is particularly important in regulating nuclear transport during cell signaling, differentiation, and immune responses. It has roles in viral infections, where it mediates the nuclear import of viral proteins such as influenza and HIV components, aiding viral replication. Dysregulation of KPNA3 is associated with neurological disorders and cancer, where it influences nuclear transport of transcription factors and oncogenes. Knockout and functional studies show its essential role in maintaining cellular homeostasis and regulating nuclear import efficiency during development and stress responses.

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