Karyopherin Alpha 1 (KPNA1) Antibody (Biotin)
169€ (20 µg)
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Name
Karyopherin Alpha 1 (KPNA1) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx105549
Tested Applications
ELISA
Description
Importin subunit alpha-5 Antibody (Biotin) is a Rabbit Polyclonal antibody against Importin subunit alpha-5 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Karyopherin Alpha 1 (KPNA1) Immunogen: Recombinant human Importin subunit alpha-5 protein (8-538AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52294 |
| Gene ID | 3836 |
| OMIM | 600686 |
| Alias | KPNA1,IPOA5, NPI-1, RCH2, SRP1, Importin, Importin subunit alpha-5, karyopherin subunit alpha 1 |
| Background | Antibody anti-KPNA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
KPNA1, also known as importin-α1, is a nuclear transport adaptor protein that mediates the import of cargo proteins containing classical nuclear localization signals (NLS) into the nucleus. It forms a heterodimer with importin-β, which facilitates the translocation of the cargo-importin complex through the nuclear pore complex (NPC) via energy-dependent mechanisms. KPNA1 is widely expressed and plays a critical role in nuclear-cytoplasmic transport during processes like transcription regulation, cell cycle progression, and stress responses. KPNA1 is involved in viral infection, where it mediates the nuclear import of viral proteins. Dysregulation of KPNA1 is linked to diseases such as cancer, where altered nuclear transport enhances oncogenic signaling. Knockout studies highlight its role in embryonic development, where impaired KPNA1 function leads to defects in gene regulation and cell growth.
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