Human Karyopherin Alpha 1 (KPNa1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein KPNA1
proveedor
Abbexareference
abx067599Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Karyopherin Alpha 1 (KPNa1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
KPNA1, also known as importin-α1, is a nuclear transport adaptor protein that mediates the import of cargo proteins containing classical nuclear localization signals (NLS) into the nucleus. It forms a heterodimer with importin-β, which facilitates the translocation of the cargo-importin complex through the nuclear pore complex (NPC) via energy-dependent mechanisms. KPNA1 is widely expressed and plays a critical role in nuclear-cytoplasmic transport during processes like transcription regulation, cell cycle progression, and stress responses. KPNA1 is involved in viral infection, where it mediates the nuclear import of viral proteins. Dysregulation of KPNA1 is linked to diseases such as cancer, where altered nuclear transport enhances oncogenic signaling. Knockout studies highlight its role in embryonic development, where impaired KPNA1 function leads to defects in gene regulation and cell growth.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Karyopherin Alpha 1 (KPNa1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 33.3 kDa Observed MW (SDS-PAGE): 29 kd Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu239-Thr506 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
KPNA1
dry ice
No
availability
Shipped within 5-7 working days.
alias
KPNA1,IPOA5, NPI-1, RCH2, SRP1, Importin, Importin subunit alpha-5, karyopherin subunit alpha 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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