IWS1, SUPT6H Interacting Protein (IWS1) Antibody
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Description
IWS1 Antibody is a Rabbit Polyclonal Antibody against IWS1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | IWS1, SUPT6H Interacting Protein (IWS1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96ST2 |
| Gene ID | 55677 |
| NCBI Accession | NP_060439.2 |
| Background | Antibody anti-IWS1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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IWS1 antibody
Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
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IWS1, SUPT6H Interacting Protein (IWS1) Antibody
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IWS1, SUPT6H Interacting Protein (IWS1) Antibody
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