Islet Amyloid Polypeptide (IAPP) Antibody

Este producto es parte de IAPP- Islet Amyloid Polypeptide
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169€ (20 µg)

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935106861
info@markelab.com
name
Islet Amyloid Polypeptide (IAPP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx109947
tested applications
ELISA, WB, IHC

Description

Islet amyloid polypeptide Antibody is a Rabbit Polyclonal antibody against Islet amyloid polypeptide.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetIslet Amyloid Polypeptide (IAPP)
HostRabbit
ReactivityHuman, Mouse
Recommended DilutionWB: 1/500 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
Purity> 95%
PurificationPurified by Protein G.
Size 120 µg
Size 250 µg
Size 3100 µg
Size 4200 µg
Size 51 mg
FormLiquid
Tested ApplicationsELISA, WB, IHC
Buffer0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP10997
Gene ID3375
OMIM147940
AliasAmylin,IAP,Diabetes-Associated Peptide Diabetes-Associated Peptide
BackgroundAntibody anti-IAPP
StatusRUO
NoteConcentration: 2.945 mg/ml -

Islet amyloid polypeptide (IAPP), also known as amylin, is a 37-residue peptide hormone produced by the pancreatic beta cells. IAPP plays a role in regulating glucose metabolism, primarily by slowing gastric emptying and reducing glucagon secretion. in conditions such as type 2 diabetes mellitus, IAPP can misfold and aggregate, forming amyloid fibrils. These amyloid fibrils can accumulate in the pancreas, particularly in the islets of Langerhans. This aggregation of amyloid fibrils is associated with beta cell dysfunction, apoptosis , and progression of type 2 diabetes. Amyloid deposits originating from islet amyloid polypeptide (IAPP), are frequently observed in the pancreatic islets of individuals with type 2 diabetes mellitus or those afflicted with insulinoma cancer. Although the connection between amylin and the onset of type 2 diabetes has been recognized for some time, pinpointing its direct causative role has proved challenging. Some research indicates that amylin, and beta-amyloid (Abeta) linked to Alzheimer's disease, could trigger apoptotic cell death in insulin-producing beta cells. This effect may have implications for the progression of type 2 diabetes.

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