Human Islet Amyloid Polypeptide (IAPP) CLIA Kit
643.5€ (96 tests)
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name
Human Islet Amyloid Polypeptide (IAPP) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195533
tested applications
CLIA
Description
Human Islet Amyloid Polypeptide (IAPP) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Islet Amyloid Polypeptide (IAPP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Islet Amyloid Polypeptide (IAPP) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | 9.38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Amylin,IAP,Diabetes-Associated Peptide Diabetes-Associated Peptide |
| Background | CLIA Kits IAPP |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Islet amyloid polypeptide (IAPP), also known as amylin, is a 37-residue peptide hormone produced by the pancreatic beta cells. IAPP plays a role in regulating glucose metabolism, primarily by slowing gastric emptying and reducing glucagon secretion. in conditions such as type 2 diabetes mellitus, IAPP can misfold and aggregate, forming amyloid fibrils. These amyloid fibrils can accumulate in the pancreas, particularly in the islets of Langerhans. This aggregation of amyloid fibrils is associated with beta cell dysfunction, apoptosis , and progression of type 2 diabetes. Amyloid deposits originating from islet amyloid polypeptide (IAPP), are frequently observed in the pancreatic islets of individuals with type 2 diabetes mellitus or those afflicted with insulinoma cancer. Although the connection between amylin and the onset of type 2 diabetes has been recognized for some time, pinpointing its direct causative role has proved challenging. Some research indicates that amylin, and beta-amyloid (Abeta) linked to Alzheimer's disease, could trigger apoptotic cell death in insulin-producing beta cells. This effect may have implications for the progression of type 2 diabetes.
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Human Islet Amyloid Polypeptide (IAPP) ELISA Kit
Human Islet Amyloid Polypeptide (IAPP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Islet Amyloid Polypeptide (IAPP) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Islet Amyloid Polypeptide (IAPP)
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