Islet Amyloid Polypeptide (IAPP) Antibody
364€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Islet Amyloid Polypeptide (IAPP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230384
tested applications
ELISA, IHC
Description
IAPP Antibody is a Rabbit Polyclonal against Amylin (IAPP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Islet Amyloid Polypeptide (IAPP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10997 |
| Alias | Amylin,IAP,Diabetes-Associated Peptide Diabetes-Associated Peptide |
| Background | Antibody anti-IAPP |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Islet amyloid polypeptide (IAPP), also known as amylin, is a 37-residue peptide hormone produced by the pancreatic beta cells. IAPP plays a role in regulating glucose metabolism, primarily by slowing gastric emptying and reducing glucagon secretion. in conditions such as type 2 diabetes mellitus, IAPP can misfold and aggregate, forming amyloid fibrils. These amyloid fibrils can accumulate in the pancreas, particularly in the islets of Langerhans. This aggregation of amyloid fibrils is associated with beta cell dysfunction, apoptosis , and progression of type 2 diabetes. Amyloid deposits originating from islet amyloid polypeptide (IAPP), are frequently observed in the pancreatic islets of individuals with type 2 diabetes mellitus or those afflicted with insulinoma cancer. Although the connection between amylin and the onset of type 2 diabetes has been recognized for some time, pinpointing its direct causative role has proved challenging. Some research indicates that amylin, and beta-amyloid (Abeta) linked to Alzheimer's disease, could trigger apoptotic cell death in insulin-producing beta cells. This effect may have implications for the progression of type 2 diabetes.
Related Products
Islet Amyloid Polypeptide (IAPP) Antibody (Biotin)
Islet amyloid polypeptide Antibody (Biotin) is a Rabbit Polyclonal antibody against Islet amyloid polypeptide conjugated to Biotin.
Ver Producto
Mouse Islet Amyloid Polypeptide (IAPP) ELISA Kit
Mouse Islet Amyloid Polypeptide (IAPP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Islet Amyloid Polypeptide (IAPP) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Islet Amyloid Polypeptide (IAPP)
Ver Producto
Human Islet Amyloid Polypeptide (IAPP) CLIA Kit
Human Islet Amyloid Polypeptide (IAPP) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Islet Amyloid Polypeptide (IAPP).
Ver Producto