IRS1 derived peptide
364€ (5 mg)
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935106861
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name
IRS1 derived peptide
category
Proteins and Peptides
provider
Abbexa
reference
abx266441
Description
IRS1 - derived peptide is a peptide.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IRS1 derived peptide |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 1513.81 Da |
| Purity | > 95% (HPLC) |
| Size 1 | 5 mg |
| Size 2 | 10 mg |
| Size 3 | 25 mg |
| Form | Lyophilized |
| Buffer | Not applicable. |
| Availability | Shipped within 10-20 working days. |
| Storage | Store dry at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | IRS1, HIRS-1, insulin receptor substrate 1 |
| Background | Protein IRS1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IRS1 is a key adaptor protein that mediates insulin and insulin-like growth factor (IGF) signaling by interacting with the insulin receptor (IR) and IGF-1 receptor. Upon receptor activation, IRS1 is phosphorylated on tyrosine residues, recruiting downstream effectors such as PI3K and Grb2 to activate pathways like PI3K/Akt and Ras/MAPK. IRS1 regulates glucose uptake, metabolism, cell growth, and survival, playing a central role in insulin signaling. It is highly expressed in insulin-sensitive tissues like muscle, liver, and adipose. Dysregulation of IRS1 is associated with insulin resistance, obesity, type 2 diabetes, and cancer, where aberrant signaling promotes proliferation and survival. Knockout studies show growth retardation, metabolic abnormalities, and impaired glucose homeostasis, underscoring its importance in metabolism and cellular signaling.
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