IRS-1 (pS307) Cell ELISA Kit
546€ (2 × 96 tests)
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935106861
info@markelab.com
name
IRS-1 (pS307) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595993
tested applications
ELISA
Description
IRS-1 (pS307) Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | IRS-1 (pS307) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Fluorometric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 2 × 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P35568 |
| Gene ID | 3667 |
| OMIM | 125853 |
| Alias | IRS1, HIRS-1, insulin receptor substrate 1 |
| Background | Elisa kits for IRS1 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IRS1 is a key adaptor protein that mediates insulin and insulin-like growth factor (IGF) signaling by interacting with the insulin receptor (IR) and IGF-1 receptor. Upon receptor activation, IRS1 is phosphorylated on tyrosine residues, recruiting downstream effectors such as PI3K and Grb2 to activate pathways like PI3K/Akt and Ras/MAPK. IRS1 regulates glucose uptake, metabolism, cell growth, and survival, playing a central role in insulin signaling. It is highly expressed in insulin-sensitive tissues like muscle, liver, and adipose. Dysregulation of IRS1 is associated with insulin resistance, obesity, type 2 diabetes, and cancer, where aberrant signaling promotes proliferation and survival. Knockout studies show growth retardation, metabolic abnormalities, and impaired glucose homeostasis, underscoring its importance in metabolism and cellular signaling.
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