Intermediate-Early Receptor Protein (NR4A2) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Intermediate-Early Receptor Protein (NR4A2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx235936
tested applications
ELISA, IHC
Description
Nurr1/NR4A2 Antibody is a Rabbit Polyclonal against Nurr1/NR4A2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Intermediate-Early Receptor Protein (NR4A2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43354 |
| Gene ID | 4929 |
| OMIM | 601828 |
| Alias | NOT,RNR1,HZF-3,IDLDP,NURR1,TINUR,Immediate-early response protein NOT,Orphan nuclear receptor NURR1 |
| Background | Antibody anti-NR4A2 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Nuclear receptor subfamily 4 group A member 2 (NR4A2), also known as NURR1, is a nuclear receptor that plays a critical role in the development and maintenance of the central nervous system, particularly in dopaminergic neurons NR4A2 is expressed in areas of the brain involved in movement, such as the substantia nigra, and it regulates the expression of genes involved in the differentiation and survival of dopaminergic neurons NR4A2 is crucial for the proper functioning of the brain's motor control system and has been implicated in the pathophysiology of neurological disorders such as Parkinson's disease, where dopaminergic neuron degeneration leads to motor deficits In addition to its role in the nervous system, NR4A2 also modulates immune responses and inflammation, making it important in the regulation of neuroinflammation Dysregulation of NR4A2 expression has been associated with neurodegeneration and psychiatric disorders, and it represents a potential therapeutic target for Parkinson's disease and other neurological conditions
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