Interleukin 8 Receptor Beta / IL8RB (CXCR2) Antibody

Este producto es parte de CXCR - C-X-C motif chemokine receptor
Product Graph
299€ (100 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Interleukin 8 Receptor Beta / IL8RB (CXCR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx177209
tested applications
WB, IHC, IF/ICC

Description

Interleukin 8 Receptor Beta (IL8Rb) Antibody is a Rabbit Polyclonal antibody against Interleukin 8 Receptor Beta (IL8Rb).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 8 Receptor Beta / IL8RB (CXCR2)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
CXCR2,C-X-C motif chemokine receptor 2,CD182,IL8R2,IL8RA,IL8RB,CMKAR2,WHIMS2,CDw128b,KC receptor,CXC-R2,high affinity interleukin-8 receptor B,CD128,Gpcr16
Background
Antibody anti-CXCR2
Status
RUO

Descripción

CXCR2 is a G protein-coupled receptor that binds IL-8 and other CXC chemokines like Groα, Groβ, and NAP-2. It is mainly expressed on neutrophils, endothelial cells, and monocytes, mediating chemotaxis, neutrophil activation, and cytokine release during inflammation. CXCR2 signaling activates pathways such as PI3K, MAPK, and NF-κB, while its rapid desensitization and internalization regulate signal duration. CXCR2 is critical for immune surveillance and inflammation but also contributes to diseases like COPD, asthma, and rheumatoid arthritis due to excessive neutrophil infiltration. In cancer, CXCR2 promotes tumor progression, angiogenesis, and metastasis by recruiting myeloid-derived suppressor cells (MDSCs) and endothelial cells to the tumor microenvironment, enhancing immunosuppression and vascularization. CXCR2 inhibition reduces tumor growth and inflammation, highlighting its therapeutic potential. It also regulates leukocyte trafficking and tissue repair but contributes to pathologies like cystic fibrosis and inflammatory bowel disease (IBD) when dysregulated. Overall, CXCR2 is key for immune cell recruitment and inflammation, balancing host defense with disease progression.

Related Products

EH4313

Human CXCR2 (C-X-C chemokine receptor type 2) ELISA Kit

Ver Producto
EM1613

Mouse CXCR2 (C-X-C chemokine receptor type 2) ELISA Kit

Ver Producto
ER1623

Rat CXCR2 (C-X-C chemokine receptor type 2) ELISA Kit

Ver Producto